The scientific program of the Research Training Group will be divided into three synergistic work packages entitled the Identification of target antigens for vaccination and immunotherapy (section 1), Vaccines, carrier proteins and adjuvants (section 2) and Immunotherapies and signaling in chronic inflammation and cancer (section 3).

• Project A1: Prof. Dr. med. Ugur Sahin
  Induction of antitumoral autoantibodies against cancer cell surface antigens using chimeric virus like particles
  
  
• Project A2: Dr. Hans Christian Probst and Prof. Dr. rer. nat. Hansjoerg Schild
  Dendritic Cell Licensing for Cytotoxic T-Cell Priming
  
  
• Project A3: Prof. Dr. med. Thomas Wölfel
  Immune barriers to the recognition of leukemia cells by antigen-specific T cells
  
  
• Project A4: PD Dr. med. Wolfgang Herr
  Identification of naturally processed peptide epitopes recognized by leukemia-reactive CD8+ cytotoxic T lymphocyte clones
  
  
• Project A5: Prof Dr. med. Stephan Grabbe
  Relevance of altered immunological synapse formation for retrovirus-induced immunosuppression

• Project A6: Prof. Dr. med. Matthias Theobald
  The immunobiology of therapeutic, p53-specific T cell antigen receptor (TCR) gene transfer
  

• Project B1: Prof. Dr. rer. nat. Jürgen Markl
  3D reconstruction and recombinant expression of the tumour vaccine carrier KLH
  
  
• Project B2: Prof. Dr. rer. nat. Heinz Decker
  Comparison of crystal and solution structures of arthropod hemocyanins
  
  
• Project B3: Prof. Dr. med. Bodo Plachter
  Analysis of human cytomegalovirus particle morphogenesis for optimization of a subviral particle vaccine
  
  
• Project B4: Prof. Dr. med. Esther von Stebut-Borschitz
  Induction of L. major-specific protection using proinflammatory signals as adjuvants

• Project C1: Prof. Dr. rer. nat. Susetta Finotto
  Regulation of CD4+ T cell cytokine signal transduction in lung adenocarcinoma and allergic asthma
  
  
• Project C2: Prof. Dr. med. Markus F. Neurath
  Functional role of the guanosine exchange factor vav1 in experimental colitis and colitis associated colon cancer
  
  
• Project C3: Prof. Dr. Dr. Detlef Schuppan
  In vivo delivery of siRNA to block hepatic inflammation and fibrogenesis
  
  
• Project C4: Prof. Dr. rer. nat. Edgar Schmitt and Dr. rer. nat. Tobias Bopp
  Studies on the function of A-Kinase Anchoring Proteins (AKAPs) for cAMP-dependent suppression of naturally occurring regulatory T cells (nTregs)
  
  
• Project C5: PD Dr. rer. nat. Christoph Becker
  Functional role of the autophagy protein ATG7 in experimental colitis and colitis associated colon cancer
  
  
• Project C6: Prof. Dr. rer. nat. Ari Waisman
  The role of IL-17A and IL-17F in autoimmune diseases
  
  
• Project C7: Prof. Dr. med. Frauke Zipp
  How do non-myelin-specific T cells contribute to neuronal damage in chronic neuroinflammation?
  
  
• Associated Project C8: Prof. Dr. rer. nat. Walter Stöcker (supported by the FZI*)
  Proteolytic processing in the Treg-mediated immune response
  
  
  *Forschungszentrum Immunologie (http://www.fzi-mainz.de/)
  
  
  
  

Z project: PD Dr. med.vet. Kurt Reifenberg
Animal housing